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This replaces the dopamine deficiency experienced during nicotine withdrawal (nicotine causes a release of dopamine which enhances the pleasure-seeking pathways in the brain reducing nicotine intake means these pathways are no longer being stimulated bupropion counteracts this effect). Bupropion is thought to be effective for smoking cessation because of its ability to increase dopamine levels in the nerve synapse by inhibiting the reuptake of dopamine.Studies confirm that bupropion is still effective for treating mood disorders, such as depression, even though the way it works is unknown. Bupropion does not affect the reuptake of serotonin or inhibit monoamine oxidase. Experts do not know exactly how bupropion works in depression but historically it was thought to be due to its ability to inhibit the reuptake of two neurotransmitters, norepinephrine, and dopamine (although this reuptake inhibition is weak).Bupropion is an antidepressant that may also be used to help people quit smoking.Medically reviewed by Carmen Fookes, BPharm.
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